Occupational asbestos exposure and gastrointestinal cancers

In brief

  • Asbestos is classified as carcinogenic to humans by the WHO’s International Agency for Research on Cancer (IARC) and identified as a specific cause of pleural and peritoneal mesothelioma and cancers of the lung, larynx and ovary, primarily among occupationally exposed workers.
  • Previous epidemiological evidence for occupational asbestos exposure as a cause of gastrointestinal cancers among workers has been suggestive, limited or inadequate.
  • The objective of this work was to conduct a systematic review and meta-analyses of occupational asbestos exposure and esophageal, stomach and colorectal cancer risk, including a critical exposure assessment approach.
  • The meta-analyses support a causal link between occupational asbestos exposure and the risk of esophageal, stomach, and colorectal cancer.

Key findings

  • A total of 82 (esophageal), 153 (stomach), and 144 (colorectal) papers met the inclusion criteria for the systematic review.
  • Elevated meta-relative risk (mRR) estimates were observed for any occupational asbestos exposure for esophageal (1.17 (95% CI 1.07 to 1.29)), stomach (1.14 (95% CI 1.05 to 1.23)), and colorectal cancer (1.16 (95% CI 1.08 to 1.24)).
  • There was consistency of mRR estimates and higher mRRs in meta-analyses where there was increased confidence in the categorization of highly exposed workers, including among the highest exposed workers in exposure-response studies, among asbestos insulation workers, and among workers in cohorts with a twofold or greater risk of asbestos-related lung cancer (as a strong indicator of exposure).

Learn more about our past work on mesothelioma epidemiology and prognosis and mesothelioma awareness and compensation.

Related publications

Occupational asbestos exposure and gastrointestinal cancers: systematic review and meta-analyses

Journal article
Koehoorn M, McLeod CB, Fan J, Arrandale VH, Davies HW, Dement JM, Pahwa M, Peters CE, Stayner L, Straif K, Demers PA.
Occup Environ Med. 2025 Feb 10:oemed-2024-109707. doi: 10.1136/oemed-2024-109707. Online ahead of print.

Occupational Asbestos Exposure and Gastrointestinal Cancers: Systematic Review and Meta-analysis

Report to The Workplace Safety and Insurance Board (WSIB) Ontario
Koehoorn M, Demers PA, McLeod CB, Arrandale V, Davies HW, Dement J, Fan J, Pahwa M, Peters CE, Stayner L, Straif K.
Vancouver, BC: Partnership for Work, Health and Safety; 2023.

Contact: Mieke Koehoorn

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